The most effective core build for Fizz Mid in Patch 16.2.1 consists of Luden's Echo, Lich Bane, and Zhonya's Hourglass, which has a 59.3% win rate. Another excellent choice is the combination of Lich Bane, Zhonya's Hourglass, and Rabadon's Deathcap with a 56.5% win rate. You should start with Doran's Ring and Health Potions and prioritize Sorcerer's Shoes for your boots.